SLU-PP-332

What it is

SLU-PP-332 is an experimental small-molecule agonist of the estrogen-related receptors (ERRs). Despite being grouped with peptides in online “research compound” discussions, it is not a peptide — it is a synthetic small molecule. It is not an approved drug and has been studied so far almost entirely in mice.¹

It is included on this site for accuracy, because it is frequently marketed alongside metabolic peptides as an “exercise mimetic.”

How it works

The estrogen-related receptors (ERRα, ERRβ, ERRγ) are transcription factors that help regulate mitochondrial function and energy metabolism — pathways that are also activated by endurance exercise. SLU-PP-332 is designed to activate these receptors, with the idea of triggering some of the metabolic adaptations associated with exercise without the exercise itself.^1,2 This is the basis for the “exercise mimetic” description.

What the evidence shows

Animal studies

In mouse studies, SLU-PP-332 has been reported to increase running endurance and to shift energy metabolism in directions consistent with improved oxidative capacity.² These are genuinely interesting early findings, but they are confined to animal models.

Human studies

There are no published human clinical trials of SLU-PP-332.² Any claim about benefits, dosing or safety in people is therefore unsupported by human evidence. This is the single most important point: it is a very early-stage research chemical.

Dosages reported in the literature

Informational only. The figures below refer to research settings; they are not a recommendation or a prescription. SLU-PP-332 is experimental, has no human data, and no safe or effective human dose exists.

Because there is no human research at all, nothing here should be read as a usable dose.

Safety & side effects

There are no human safety data for SLU-PP-332.² Its risk profile in people is entirely unknown, including any long-term consequences of broadly activating ERR pathways. As with all unregulated research chemicals, product identity and purity sold online cannot be assumed to match the labeled compound.

Legal & regulatory status

SLU-PP-332 is not approved by the FDA for any use; it is an experimental research chemical. In sport, compounds that mimic exercise adaptations or modulate metabolism fall under restricted anti-doping categories, so it should be treated as prohibited for athletes subject to those rules; check current WADA guidance. Rules differ by country and change over time.³

References

1. Billon C, Sitaula S, Banerjee S, Welch R, Elgendy B, Hegazy L, Oh TG, Kazantzis M, Chatterjee A, Chrivia J, Hayes ME, Xu W, Hamilton A, Huss JM, Zhang L, Walker JK, Downes M, Evans RM, Burris TP. Synthetic ERRα/β/γ Agonist Induces an ERRα-Dependent Acute Aerobic Exercise Response and Enhances Exercise Capacity. ACS Chem Biol. 2023;18(4):756-771. doi:10.1021/acschembio.2c00720. [PMID 36988910, doi:10.1021/acschembio.2c00720]
2. Billon C, Sitaula S, Banerjee S, et al. Synthetic ERRα/β/γ Agonist Induces an ERRα-Dependent Acute Aerobic Exercise Response and Enhances Exercise Capacity. ACS Chem Biol. 2023;18(4):756-771. doi:10.1021/acschembio.2c00720. [PMID 36988910, doi:10.1021/acschembio.2c00720]
3. World Anti-Doping Agency. The Prohibited List. World Anti-Doping Agency, Montreal. Available at: https://www.wada-ama.org/en/prohibited-list (S0 Non-Approved Substances; S4 Hormone and Metabolic Modulators). [wada-ama.org]